Olfactics and Olfactory Theranostics

Monday, April 23, 2018

Conference Presentation by Danny Kunz

Monday, April 23, 2018 Conference Presentation by Danny Kunz https://drive.google.com/file/d/1YryRbLVTJW9FXHg2R8pnaa1jHZJqH5uR/view As usual, Danny Kunz most graciously provided the MEBO community with a very informative PowerPoint presentation on the Causes of Body Odor. This PowerPoint was to be presented and discussed at length at the MEBO Annual Conference, Savannah, Georgia 2018. Since we did have some technical difficulties and we were unable to hear the video, I am now presenting it here. Discussion below on some points of interest that Danny tells us: Histamine in the gut is bad because it has a strong impact on tight junction regulation of intestinal cells. In fact, "fecal body odor seems to be related to histamine degradation deficiency" The significance of gut wall health (tight junction regulation of intestinal cells) was discussed in the conference. Sufferers are recommended to consult with their physician if they experience prolonged allergic reactions, especially of the bowels, such as food sensitivities and/or indigestion, etc. It is important to maintain good health of the digestive tract in the fight against odor conditions and PATM. Sufferers are recommended to consult with their gastroenterologist when experiencing any intestinal discomfort, including but not limited to, bloating, constipation, diarrhea, abdominal tenderness, painful bowel movement, hemorrhoids, rectal bleeding, etc. It looks like histamine concentrations are highly important for the tight junction regulation of intestinal cells. The tight junctions are important for the direct paracellular transport of electrolytes into the blood without transition through the intestinal cell metabolism. Increased open tight junctions [leaky gut] will further lead to an increased surface area of the intestinal cells [IBS] and are as a result, a strong regulator of passing amines and their level of being processed. http://bodyodorresearch.blogspot.com/2017/05/histamine-has-strong-impact-on-tight.html Clinical significance of the opening of intercellular tight junctions (increased intestinal permeability), any of which may result in opening of tight junction, resulting in the passing of electrolytes into the blood without transition through the intestinal cell metabolism. Clinical significance [Wikipedia] The opening of intercellular tight junctions (increased intestinal permeability) allows uncontrolled passage of substances into the bloodstream, with subsequent possible development of immune and/or inflammatory reactions.[3][8] The opening of intercellular tight junctions (increased intestinal permeability) can allow passage of microbes, microbial products, and foreign antigens into the mucosa and the body proper. This can result in activation of the immune system and secretion of inflammatory mediators.[12] Increased intestinal permeability is a factor in several diseases, such as Crohn's disease, celiac disease,[13] type 1 diabetes,[14]type 2 diabetes,[13] rheumatoid arthritis, spondyloarthropathies,[15] inflammatory bowel disease,[8][16] irritable bowel syndrome,[9]schizophrenia,[17][18] certain types of cancer,[8] obesity,[19] fatty liver,[20] atopy and allergic diseases,[14] among others. In the majority of cases, increased permeability develops prior to disease,[8] but the cause–effect relationship between increased intestinal permeability in most of these diseases is not clear.[16][21] For a clearer understanding of the above used terms, see illustration below: Transcellular route (pathway): The route through cells, as opposed to between the cells. Paracellular route: the route between cells Tight junction: A type of cell junction formed between epithelial cells of vertebrates wherein the outer layers of two adjacent cells fuse, thereby serving as a barrier to the passage of fluid between cells An informative site on Crohn's Disease: Verywell.com, a health & wellness site that provides simple, expert advice to 20M readers a month, https://www.verywellhealth.com/crohns-disease-4013910 ----------------------------- María María de la Torre Founder and Executive Director https://web.archive.org/web/20250821224117/https://www.meboblog.com/search/label/powerpoint https://web.archive.org/web/20251112182112/https://www.meboblog.com/

Wednesday, March 14, 2018

Microbes of anti-social odor

Human odors depend on many extrinsic (such as food or clothing) and intrinsic factors - localized or systemic. In recent years, microbes responsible for localized malodors - bad breath caused by oral bacteria and axillary odor - have been mapped by using next generation sequencing approaches. However, intestinal microbes responsible for systemic malodor (whole-body and extraoral halitosis), remain to be identified.

Our preliminary analysis of culture-, PCR- and 16S-RNA-based data donated by MEBO and PATM community members show that there are no easy answers.

Monday, May 22, 2017

Unraveling the Mysteries of Mischievous Microbiome

Science explains why some people smell worse than others despite keeping themselves squeaky clean.

The body is crawling with microbes that have evolved with the person, depending on the innate metabolism, history of infections, microbiome swaps, diet and lifestyle. The body's ecosystem of microorganisms can increase the risk for dangerous diseases for which we have unreserved levels of sympathy. It can also lead to unlikable conditions such as unpredictable and embarrassing outbursts of odor emitting through the pores - odor so bad it ruins social lives and careers.

Monday, May 8, 2017

Let those who never smelled bad cast the first stone

Analysis of our metabolism is crucial to comprehending the responses of our genes and microbes to the stresses of daily life, and to elucidating the causes and consequences of health and disease.

We applied metabolomic approach to an elusive condition that has always evaded diagnosis: socially and psychologically distressing odors that occur without a known or apparent cause. Learn about our preliminary results and participate in our anonymous survey to help us better understand and help with this condition.

Sunday, May 7, 2017

Summary of MEBO discussion on May 7, 2017

In a Skype call held on May 7, 2017, by MEBO Research, moderated by María de la Torre, the main objective was to discuss strategies for managing body odor (associated with conditions such as TMAU or other metabolic disorders) through lifestyle and dietary changes.

Key points discussed:

Hormonal influence: The discussion covered how hormonal changes in adolescents (up to around age 21), women (during the menstrual cycle), and stressful situations (through adrenaline release) can influence or trigger odor symptoms (1:08–2:07; 14:31–15:24).

Diet and nutrition:

Natural, whole foods are preferable to processed foods in order to avoid unnecessary chemicals (3:33–4:05).

Foods high in sulfur (such as garlic and onions) should be limited or thoroughly cooked (for example, sautéed) so that odor-causing compounds evaporate before consumption (4:05–5:23).

It was emphasized that choline is an essential nutrient and should not be completely eliminated from the diet, as a deficiency can cause serious damage to the nervous system and increase anxiety (9:58–11:30).

Body detoxification process: It was explained that the body needs time to eliminate odor-causing chemicals that have accumulated in fatty tissues over the years. Drinking plenty of water and engaging in cardiovascular exercise can help speed up this process by mobilizing these compounds so they can be eliminated through sweat, urine, and breathing (5:26–7:43; 12:51–13:47).

Emotional well-being: The discussion addressed how social fear and anxiety about possibly smelling bad can create a vicious cycle that negatively affects psychological well-being (10:38–11:30).

Wednesday, April 12, 2017

My hope: TMAU short

Wednesday, April 12, 2017

VIDEO "My hope: Tmau short"

My hope: Tmau short
by TheoMeta
W.K. Elohim Productions
March 30, 2017

One of our community members found this TMAU short film and shared it with me. For the first time ever, it was actually optimistic and full of hope.

I do believe we have come a long way, as we continue steadfastly on the path looking for answers that we hope will arrive sooner than later. There is currently more hope now because there are many "fronts" from which we are expecting new discoveries, and that is most promising, uplifting and inspiring.

Thank you TheoMeta for doing this film and for allowing me to post it in the MEBO Blog! Sharing the hope saves lives. We must keep sharing.

María

Tuesday, April 11, 2017

Metabolic Pathway Simulation: Apocrine Bromhidrosis compared to TMAU

METABOLIC PATHWAY SIMULATIONS

APOCRINE BROMHIDROSIS

COMPARED TO TRIMETHYLAMINURIA

Danny.kunz@gmx.de

Click for presentation

Danny Kunz has donated a very interesting PowerPoint presentation for the MEBO Conference 2017 consisting of metabolic pathway simulations on Apocrine Bromhidrosis compared to Trimethylaminuria. This presentation also discusses the role of the eccrine glands in bromhidrosis.

We are most grateful to Danny, who is a part of this, "loosely coupled group of patients (and non-patients) with academic degree and without academic degree integrating our separate research capabilities and representing an addressable unit."

This theory is supported by high throughput simulations backed by large enzyme databases, which makes it a very persuasive presentation. In other words, this group has done a computer simulation of bromhidrosis backed up by large enzyme databases, as Danny explains in the presentation. Their theory is that bromhidrosis is an apocrine and eccrine sweat glands metabolic disease. Danny also says in his presentation that thyroid function with and without elevated hormone, TSH, may plays a role in bromhidrosis, and the group recommends supplementation and diet for this.

Even though the simulations discussed in this PowerPoint presentation do not have the aspect of medical proof yet, it provides a very compelling theory that calls for further research.

TOPIC OF THE PRESENTATION:

1. Fecal (indole) breath and body odor and it's recommended supplementation and diet,

2. Apocrine and eccrine sweat glands metabolic disease in bromhidrosis,

a. Discussions on isovaleric acid and amino acid leucine in eccrine bromhidrosis,

b. Recommends a Thyroid functions blood test, with and without elevated Thyroid Stimulating Hormone (TSH), and recommended supplementation and diet.

This very interesting presentation raises question on whether TMAU2 to TMAU1 relation pattern could be transferred to the Bromhidrosis pattern as well.