Showing posts with label TMAU. Show all posts
Showing posts with label TMAU. Show all posts

Tuesday, January 10, 2012

Studying body odor: one step at a time

Unpleasant body odors could be a sign of a disease. But even when the cause of the disease is known - an example is trimethylaminuria or TMAU - there are no one-size-fits-all solutions. Elimination of choline and other essential nutrients from diet can be harmful and unhelpful.  Everyone has their own unique needs, with individual combinations of foods, activities and optimal environmental conditions.

An earlier survey of about 100 body odor and halitosis sufferers indicated stress (34%), food (25%) and environment, including the weather and perfumed products (15%) as main triggers of odors. 23% of sufferers did not know what the trigger was.

Our study seems to have less unknowns. As you see from the picture, 60% of participants have both body odor and halitosis. Only 22% of participants were diagnosed with TMAU, one third has IBS, one third has environmental sensitivities (mostly pollen and mold allergies, but some have dust mite and pet allergies and chemical sensitivities). Over 60% of participants reported sensitivities to specific foods. Most frequent was lactose sensitivity.

It is known that a specific diet, infections and diseases have major impact on variations in human body odor.  Some of our early results on fatty and ammonia types of odors identified a few food ingredients and their maldigestion as potential causes. Our next posts on musty and smoky odors, as well as unpleasant odors in general will tell more.

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 for more information

And stay tuned for results!

Jan Havlicek, & Pavlina Lenochova (2008). Environmental effects on human body odour Chemical Signals in Vertebrates DOI: 10.1007/978-0-387-73945-8_19

Havlicek, J., & Lenochova, P. (2006). The Effect of Meat Consumption on Body Odor Attractiveness Chemical Senses, 31 (8), 747-752 DOI: 10.1093/chemse/bjl017

Moshkin M, Litvinova N, Litvinova EA, Bedareva A, Lutsyuk A, Gerlinskaya L. Scent Recognition of Infected Status in Humans. J Sex Med. 2011 Dec 6. doi: 10.1111/j.1743-6109.2011.02562.x.

Monday, December 5, 2011

The Road to Ammonia

Why do I smell like Ammonia? This question, in thousands of variations, has been asked over and over again at every major question/answer site, especially teen, bodybuilding and athletic forums.

The Internet provides plenty of opinions.

Medical sites talk about diseases like chronic kidney failure, hepatic cirrhosis or H. pylori infection. Fitness sites recommend drinking more water, reevaluating protein sources and eating more carbohydrates.
What are these diet-odor links? And what's the Science? Ammonia may be formed during the alkaline hydrolysis and deamidation of proteins - by our own metabolism and the metabolism of microbes that call us home. If our kidneys can't handle the load of nitrogen, it's excreted as ammonia in sweat. Excretion increases 10 times as temperature goes from 70 to 100 Fahrenheit.

Aurametrix is a breakthrough analysis tool that correlates users' actions and reactions based on what information they enter into the system. Preliminary correlations in the Aurametrix knowledge base show exactly what's expected: excess protein does lead to ammonia-like odor.

But wait a minute - does it say the same about excess fat?

An  example provided by one of our users is very interesting. The user logged a few foods he thought were contributing to odor. These were different odors according to the user - ranging from "Ammonia-like" to "Fishy", sharp, cloying and stale. Aurametrix, however, recognized that all these odors described by the user may be related to nitrogen-containing compounds.  When these three data points were analyzed along with four foods that the user did not associate with any odors, Aurametrix displayed only one result:

Based on your Aura entries, the following may be contributing to "Ammoniacal odor" in a 3 hour timeframe:

Hexadecanoic acid  - commonly known as Palmitic acid - is one of the most common saturated fatty acids in the Western diet. Palm oil and coconut oil contain especially high levels of this acid. What effect does this acid have on metabolism? It down-regulates glycose metabolism and protein metabolism, affecting Calcium or mRNA binding proteins [1]. So there may very well be a connection!

Want to connect the dots to your own health and wellbeing and see what you have in common with others?

Write to:


Hovsepyan, M., Sargsyan, E., & Bergsten, P. (2010). Palmitate-induced changes in protein expression of insulin secreting INS-1E cells Journal of Proteomics, 73 (6), 1148-1155 DOI: 10.1016/j.jprot.2010.01.012

Trabue S, Kerr B, Bearson B, Ziemer C. Swine odor analyzed by odor panels and chemical techniques. J Environ Qual. 2011 Sep-Oct;40(5):1510-20.

Ito, Shigeji; Kohli, Yoshihiro; Kato, Takuji; Abe, Yoshimichi; Ueda, Takashi
Significance of ammonia produced by Helicobacter pylori. European Journal of Gastroenterology & Hepatology. 6(2):167-174, February 1994.

Qiu, Y.T., Smallegange, R.C., Van Loon, J.J.A., Takken, W. 2011 Behavioural responses of Anopheles gambiae sensu stricto to components of human breath, sweat and urine depend on mixture composition and concentration. Medical and Veterinary Entomology 25 (3), pp. 247-255

Enrique Wolpert, M.D., Sidney F. Phillips, M.D., and W. H. J. Summerskill, D.M. Ammonia Production in the Human Colon — Effects of Cleansing, Neomycin and Acetohydroxamic Acid N Engl J Med 1970; 283:159-164

V Bhatia, R Singh, S K Acharya Liver: Predictive value of arterial ammonia for complications and outcome in acute liver failure. Gut 2006;55:98-104 Published Online First: 15 July 2005 doi:10.1136/gut.2004.061754

Consolazio, C.F., Nelson, R.A., Matoush, L.O., Canham, J.E. Nitrogen excretion in sweat and its relation to nitrogen balance requirements. J Nutr. 1963 Apr; 79:399-406.

Ammonia in personal care products:
After Bite ointments
Hair dyes

Ammonia in household products:
Ammonia Removing Products
Glass Cleaners
Kitchen Cleaners