The Many Genes of TMAU

Twenty years ago Trimethylaminuria was linked to mutations in the FMO3 gene. It turns out there are many more genes that can lead to this condition. 

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The Smell of COVID-19

 From oatmeal cookies, rotting apples and burnt chocolate to bleach, gasoline and the smell of wet dog - all infections have a distinct odor signature. Is there a signature for COVID-19?

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Microbial diagnostics of MEBO

There are many medical conditions for which there are no standard tests for definite diagnosis and no established cures.  Diagnosing and curing Metabolic Body Odor (MEBO) is even more difficult. Especially because MEBO is an umbrella term for several different conditions.

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Gender - confounder of concern?

Background and clinical characteristics measured at baseline are comparable in the groups of our study. But this doesn't eliminate the need to investigate the impact of confounding. We've already analyzed the effects of age, What about gender as a potential confounder?

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Age and Metabolic Body Odor

MEBO is a complex condition and while some of the cases seem simpler, non-linear analysis approaches are better equipped to handle the task.  And this creates new challenges regarding  the existence of confounding factors.

The Anna Karenina Principle: Sutterella

Sutterella group is the largest cohort identified in our study.

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Concluding the MEBO-uBiome study

We are very close to concluding our clinical trial NCT03582826 ​according to the pre-specified protocol. 

Recruitment for our microbiome study commenced in June 2018 and completed in December 2018. The last batch of raw FASTQ sequences and raw taxonomy-level abundance summaries was received in October 2019. We had to spend more time on collecting and processing annotation data (medical histories, dietary intakes, medications, etc), ensuring quality, completeness, consistency and validity, and defining best approaches of dealing with "missing values".

We have now completed final data collection for the primary and secondary outcome measures.

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