"All happy families are alike; each unhappy family is unhappy in its 
own way", said the great novelist. The Anna Karenina principle (AKP), in
 the context of metabolic disorders, would mean that an uncompensated 
deficiency in any one of important enzymes, or presence of any one of 
pathogenic microorganisms, dooms the person to having the MEBO/PATM 
symptoms.
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